Business

We have developed three business areas, 1) drug discovery research, 2) contract research, and 3) tool product sales, supporting development process in genome drug discovery, from target search to drug discovery to clinical development.

We conduct searches of target proteins applying on our own unique bioinformatics, and searches of hit/lead compounds based on rational drug design. Development of atrial fibrillation treatment from spider venoms is a good example. Although some peptides derived from venoms produced by certain spider species are known to have property to contain atrial fibrillation, they cannot be used for treatment as they are due to their high toxicities. We have successfully designed small peptide drugs using rational drug design while maintaining their active sites crucial for the pharmacological property.

In bioinformatics, we predict a protein's function according to its amino acid sequence and 3-D structure information, and evaluate how cSNP would affect its structural and functional properties. In drug design, we apply our own unique virtual screening technology to clients' needs, from selection of hit compounds for a target protein to optimization of hit compounds. We have named this service PharmaSBLD.

PharmaGPEP^TM:

Libraries of synthesized peptides as GPCR ligand candidates of which sequences were predicted from human genome sequences using our own unique informatics technologies

PharmaGCHEM^TM:

Focused libraries of low molecule compounds targeting GPCR, selected with our successful virtual screening methods

Poodle: (upcoming products)

Software to predict disorder regions in proteins. Poodle stands for Prediction Of Order and Disorder by machine LEarning.

ADMEnsa Interactive^TM*:

Comprehensive in silico ADME prediction system

*(product by BioFocus DPI, in Japan only)